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Am J Geriatr Psychiatry. 2007 Jan;15(1):84-7.

Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia.

Author information

  • 1Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA. mmendez@ucla.edu

Abstract

OBJECTIVE:

The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD).

METHODS:

Twelve patients with FTD who received donepezil for six months were compared with 12 FTD controls on behavioral measures.

RESULTS:

The groups did not differ on most variables at baseline or at six months; however, the donepezil group had greater worsening on the FTD Inventory. Four treated patients had increased disinhibited or compulsive acts, which abated with discontinuation of the medication.

CONCLUSION:

There were no changes in global cognitive performance or dementia severity; however, a subgroup of patients with FTD can experience worsening of symptoms with donepezil.

PMID:
17194818
[PubMed - indexed for MEDLINE]
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