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    J Enzyme Inhib Med Chem. 2006 Oct;21(5):531-5.

    A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens.

    Lodhi MA, Hussain J, Abbasi MA, Jassbi AR, Choudhary MI, Ahmad VU.

    Source

    Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.

    Abstract

    Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. and Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 microM.

    PMID:
    17194023
    [PubMed - indexed for MEDLINE]

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