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Ann N Y Acad Sci. 2006 Nov;1088:373-81.

Interleukin-6: a cytokine and/or a major modulator of the response to somatic stress.

Author information

  • 1Second Department of Obstetrics and Gynecology, University of Athens, Greece. mastorak@mail.kapatel.gr

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis and the proinflammatory cytokines (and interleukin-6 [IL-6] in particular) are enmeshed in the response to somatic stress, either in health or in acute or chronic disease. Usually IL-6 is elevated in states of septic (such as sepsis) or aseptic inflammation (such as rheumatoid arthritis). Exercise is a form of somatic stress. Local tissue IL-6 elevation is noted during shorter and less intense exercise, whereas brief peripheral IL-6 "bursts" are observed with longer and more intense exercise. Therapeutic interventions that target IL-6 or its soluble receptor are currently assessed, with an emphasis on autoimmune diseases and inflammatory conditions.

PMID:
17192581
[PubMed - indexed for MEDLINE]
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