Am J Crit Care. 2007 Jan;16(1):82-5.

Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury.

Sabsovich I, Rehman Z, Yunen J, Coritsidis G.

Source

Surgical and Trauma Intensive Care Unit, Elmhurst Hospital Center, Mount Sinai School of Medicine, New York, NY, USA.

Abstract

A previously healthy 16-year-old boy with a closed, severe traumatic brain injury was admitted to a surgical and trauma intensive care unit. He was given a continuous infusion of propofol for sedation and to control intracranial pressure. About 3 days after the propofol infusion was started, metabolic acidosis and rhabdomyolysis developed. Acute renal failure ensued as a result of the rhabdomyolysis. Tachycardia with wide QRS complexes developed without hyperkalemia. The patient died of refractory cardiac dysrhythmia and circulatory collapse approximately 36 hours after the first signs of propofol infusion syndrome appeared. Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug. The syndrome is characterized by severe metabolic acidosis, rhabdomyolysis, acute renal failure, refractory myocardial failure, and hyperlipidemia. Despite several publications on the subject in the past decade, most cases still seem to remain undetectable.

PMID:: 17192529; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. [J Neurosurg. 2001]
Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion.
Cannon ML, Glazier SS, Bauman LA. J Neurosurg. 2001 Dec; 95(6):1053-6.
[Propofol infusion syndrome]. [Anaesthesist. 2006]
[Propofol infusion syndrome].
Trampitsch E, Oher M, Pointner I, Likar R, Jost R, Schalk HV. Anaesthesist. 2006 Nov; 55(11):1166-8.
Propofol infusion syndrome in a patient with sepsis. [Anaesth Intensive Care. 2006]
Propofol infusion syndrome in a patient with sepsis.
De Waele JJ, Hoste E. Anaesth Intensive Care. 2006 Oct; 34(5):676-7.
Review Propofol infusion syndrome: a rare complication with potentially fatal results. [Crit Care Nurse. 2008]
Review Propofol infusion syndrome: a rare complication with potentially fatal results.
Zaccheo MM, Bucher DH. Crit Care Nurse. 2008 Jun; 28(3):18-26; quiz 27.
Review Propofol infusion syndrome: an overview of a perplexing disease. [Drug Saf. 2008]
Review Propofol infusion syndrome: an overview of a perplexing disease.
Fodale V, La Monaca E. Drug Saf. 2008; 31(4):293-303.

See reviews... See all...

Cited by 1 PubMed Central article

Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. [Crit Care. 2009]
Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study.
Roberts RJ, Barletta JF, Fong JJ, Schumaker G, Kuper PJ, Papadopoulos S, Yogaratnam D, Kendall E, Xamplas R, Gerlach AT, et al. Crit Care. 2009; 13(5):R169. Epub 2009 Oct 29.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Propofol infusion syndrome: a case of increasing morbidity with traumatic brain ...
Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury.
Am J Crit Care. 2007 Jan ;16(1):82-5.

PubMed
Nurses' implementation of guidelines for ventilator-associated pneumonia from th...
Nurses' implementation of guidelines for ventilator-associated pneumonia from the Centers for Disease Control and Prevention.
Am J Crit Care. 2007 Jan ;16(1):28-36; discussion 37; quiz 38.

PubMed
Deficits in synaptic transmission and learning in amyloid precursor protein (APP...
Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.
J Neurosci. 2006 Dec 27 ;26(52):13428-36.

PubMed
Ribosome biogenesis is sensed at the Start cell cycle checkpoint.
Ribosome biogenesis is sensed at the Start cell cycle checkpoint.
Mol Biol Cell. 2007 Mar ;18(3):953-64. Epub 2006 Dec 27 .

PubMed
Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticu...
Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.
Mol Biol Cell. 2007 Mar ;18(3):839-49. Epub 2006 Dec 27 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information