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Nat Rev Microbiol. 2007 Feb;5(2):157-61. Epub 2006 Dec 27.

H-NS, the genome sentinel.

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  • Department of Microbiology, Trinity College Dublin, Dublin, Ireland. cjdorman@tcd.ie


Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquired AT-rich genes, including those that make up its major pathogenicity islands. Broadly similar conclusions have emerged from a study of H-NS binding to DNA in Escherichia coli. How do these findings affect our view of H-NS and its ability to influence bacterial evolution?

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