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Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19824-9. Epub 2006 Dec 22.

Microinversions in mammalian evolution.

Author information

  • 1Bioinformatics Program and Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA 92093, USA. mchaisso@bioinf.ucsd.edu


We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as "certificates" to verify different branches in a phylogenetic tree, turning the challenging problem of phylogeny reconstruction into a relatively simple algorithmic problem. We estimate that there exist hundreds of thousands of microinversions in genomes of mammals from comparative sequencing projects, an untapped source of new phylogenetic characters.

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