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Mol Cell. 2006 Dec 28;24(6):809-10.

DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter.

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  • 1Department of Molecular Biology, University of Geneva, CH-1211, Geneva 4, Switzerland.

Abstract

New work by Bruno et al. (2006) describes a mechanistic switch of the proliferation-promoting Che-1 activator of E2F-target genes into a cell-cycle inhibitor in response to DNA damage, through Che-1 relocalization to, and activation of, the p53 tumor suppressor gene.

PMID:
17189183
[PubMed - indexed for MEDLINE]
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