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FEBS Lett. 2007 Jan 23;581(2):248-52. Epub 2006 Dec 18.

Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases.

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  • 1Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Rm H3143, Stanford, CA 94305-5236, USA. upadhyay@stanford.edu

Abstract

We studied the effects of fibroblast growth factor (FGF-10) on H2O2-induced alveolar epithelial cell (AEC) G1 arrest and the role of G1 cyclins. FGF-10 prevented H2O2-induced AEC G1 arrest. FGF-10 induced 2-4-fold increase in cyclin E, cyclin A and CDKs (2,4) alone and in AEC treated with H2O2. H2O2 downregulated cyclin D1; FGF-10 blocked these effects. FGF-10 prevented H2O2-induced upregulation of CDK inhibitor, p21. SiRNAp21 blocked H2O2-induced downregulation of cyclins, CDKs and AEC G1 arrest. Accordingly, we provide first evidence that FGF-10 regulates G1 cyclins and CDKs, and prevents H2O2-induced AEC G1 arrest.

PMID:
17188682
[PubMed - indexed for MEDLINE]
PMCID:
PMC1861821
Free PMC Article
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