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Curr Opin Chem Biol. 2007 Feb;11(1):99-110. Epub 2006 Dec 22.

Chemical biology of steroid and nuclear hormone receptors.

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  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark DE 19716, USA.


The nuclear hormone receptors are ligand-gated transcription factors that modulate gene expression by directly acting upon genomic DNA, and have been of profound interest across all biological disciplines. Recent advancements in this area have included the expansion of transgene activation through ligand-receptor engineering, drug development from structural design and the exploitation of innate ligand-specific associations towards developing novel conditional protein-based recombinant and diagnostic tools. These advancements come on the heels of exciting new modes of hormone action that challenge and expand upon the classic paradigms of hormone receptor function.

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