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Biochim Biophys Acta. 2007 Apr;1768(4):794-807. Epub 2006 Nov 15.

G protein coupled receptor structure and activation.

Author information

  • Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. kobilka@stanford.edu

Abstract

G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor.

PMID:
17188232
[PubMed - indexed for MEDLINE]
PMCID:
PMC1876727
Free PMC Article

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