Mol Cell. 2006 Nov 17;24(4):489-90.

Grabbing Plk1 by the PBD.

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Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.

Abstract

A new centromeric protein termed PBIP1 was identified that recruits Plk1 to the kinetochores. In the November 3 issue of Molecular Cell, show that Plk1 phosphorylates PBIP1 on threonine 78, creating its own high-affinity docking site for the polo-box domain (PBD).

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Mol Cell. 2006 Nov 3;24(3):409-22.

PMID:: 17188028; [PubMed - indexed for MEDLINE]

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Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. [Mol Cell. 2006]
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.
Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, et al. Mol Cell. 2006 Nov 3; 24(3):409-22.
Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores. [J Biol Chem. 2011]
Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.
Kang YH, Park CH, Kim TS, Soung NK, Bang JK, Kim BY, Park JE, Lee KS. J Biol Chem. 2011 Jun 3; 286(22):19744-57. Epub 2011 Mar 30.
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. [Mol Biol Cell. 2006]
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
Qi W, Tang Z, Yu H. Mol Biol Cell. 2006 Aug; 17(8):3705-16. Epub 2006 Jun 7.
Review Polo-box domain: a versatile mediator of polo-like kinase function. [Cell Mol Life Sci. 2010]
Review Polo-box domain: a versatile mediator of polo-like kinase function.
Park JE, Soung NK, Johmura Y, Kang YH, Liao C, Lee KH, Park CH, Nicklaus MC, Lee KS. Cell Mol Life Sci. 2010 Jun; 67(12):1957-70. Epub 2010 Feb 11.
Review Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. [Dev Cell. 2008]
Review Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1.
Petronczki M, Lénárt P, Peters JM. Dev Cell. 2008 May; 14(5):646-59.

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