Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2007 Jan;7(1):31-40.

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation.

Author information

  • 1Department of Translational Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA. sanj@gene.com

Abstract

The NOD-like receptors have important roles in innate immunity as intracellular sensors of microbial components and cell injury. It has been proposed that these cytosolic proteins regulate the cysteine protease caspase-1 within a multiprotein complex known as the 'inflammasome'. Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18, as well as host-cell death. The analysis of mice that are deficient in various inflammasome components has revealed that the inflammasome is a dynamic entity that is assembled from different adaptors in a stimulus-dependent manner. Here we review recent work on the activation of the inflammasome in response to various bacterial pathogens and tissue damage.

PMID:
17186029
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk