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Science. 2006 Dec 22;314(5807):1936-8.

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling.

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  • 1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037 USA.

Abstract

Innate immune signals mediated by Toll-like receptors (TLRs) have been thought to contribute considerably to the antibody-enhancing effects of vaccine adjuvants. However, we report here that mice deficient in the critical signaling components for TLR mount robust antibody responses to T cell-dependent antigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A/trehalose dicorynomycolate adjuvant. We conclude that TLR signaling does not account for the action of classical adjuvants and does not fully explain the action of a strong adjuvant containing a TLR ligand. This may have important implications in the use and development of vaccine adjuvants.

PMID:
17185603
[PubMed - indexed for MEDLINE]
PMCID:
PMC1868398
Free PMC Article
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