Semin Thorac Cardiovasc Surg. 2006 Fall;18(3):206-10.

Large-cell neuroendocrine carcinoma of the lung: an aggressive neuroendocrine lung cancer.

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Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Abstract

Large cell neuroendocrine carcinoma (LCNEC) is part of the neuroendocrine spectrum of pulmonary tumors. This increasingly recognized tumor has been reported to have 5-year actuarial survival rates following resection that are worse than those described for other variants of non-small cell lung cancer (NSCLC). Therefore, debate has emerged regarding whether the tumors should be classified and treated as NSCLC or small-cell lung cancer. This article reviews the tumor characterization, biology, presentation and diagnosis, surgical therapy, results of therapy, and long term prognosis of patients with LCNEC.

PMID:: 17185180; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Long-term disease-free survivor of metastatic large-cell neuroendocrine carcinoma of the lung treated with amrubicin and irinotecan. [Drug Des Devel Ther. 2009]
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