Nat Rev Mol Cell Biol. 2007 Jan;8(1):49-62.

Integrating cell-signalling pathways with NF-kappaB and IKK function.

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College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK. n.d.perkins@dundee.ac.uk

Abstract

Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappaB or IKK function contributes to many human diseases, including cancer. However, the NF-kappaB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate.

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