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    Retrovirology. 2006 Dec 20;3:95.

    HIV-1 Tat interaction with Dicer: requirement for RNA.

    Bennasser Y, Jeang KT.

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    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, USA. ybennasser@mail.nih.gov

    Abstract

    Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here, we have investigated the requirements for Tat interaction with Dicer. We report that Tat-Dicer interaction depends on RNA, requires the helicase domain of Dicer, and is independent of Tat's transactivation domain.

    PMID:
    17181864
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1764028
    Free PMC Article

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