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Semin Oncol. 2006 Dec;33(6 Suppl 11):S2-5.

Biomarkers of response to preoperative chemoradiation in esophageal cancers.

Author information

  • 1Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA. rluthra@mdanderson.org


To identify a panel of biomarkers that predicts response of esophageal cancers to preoperative chemoradiation, our group profiled the gene expression of pretreatment cancer biopsies from patients with esophageal cancer. Six (32%) of these patients had pathologic complete response. All cancers except one that achieved pathologic complete response (83%) clustered in one molecular type (type I), while cancers that achieved less than pathologic complete response with one exception clustered in another molecular type (type II). Activated NF-kappaB was significantly associated with aggressive pathology. These data indicate that expression analysis of a limited set of biomarkers selected from the list of genes that were differentially regulated between the two subtypes can increase predictive power, and suggest that esophageal cancer with activated NF-kappaB may result in poor treatment outcome.

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