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    J Am Chem Soc. 2006 Dec 27;128(51):16476-7.

    Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe.

    Leevy WM, Gammon ST, Jiang H, Johnson JR, Maxwell DJ, Jackson EN, Marquez M, Piwnica-Worms D, Smith BD.

    Source

    Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.

    Abstract

    An optical imaging probe was synthesized by attaching a near-infrared carbocyanine fluorophore to an affinity group containing two zinc(II) dipicolylamine (Zn-DPA) units. The probe has a strong and selective affinity for the surfaces of bacteria, and it was used to image infections of Gram-positive S. aureus and Gram-negative E. coli bacteria in living nude mice. After intravenous injection, the probe selectively accumulates at the sites of localized bacterial infections in the thigh muscles of the mice.

    PMID:
    17177377
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2531239
    Free PMC Article

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