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Immunity. 2006 Dec;25(6):862-4.

Maintaining hematopoietic stem cells in the vascular niche.

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  • 1Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.

Abstract

In this issue of Immunity, Sugiyama et al. (2006) provide evidence that most bone-marrow hematopoietic stem cells (HSCs) reside in vascular niches containing reticular cells that secrete CXCL12, a chemokine that promotes HSC maintenance.

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PMID:
17174928
[PubMed - indexed for MEDLINE]
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