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Cell. 2006 Dec 15;127(6):1083-6.

RNA interference: big applause for silencing in Stockholm.

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  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu

Abstract

Eight years ago, Craig Mello, Andrew Fire, and their coworkers provided the first demonstration that double-stranded RNA (dsRNA) triggers the gene-silencing technique that we now call RNA interference (RNAi). For this landmark discovery, Mello and Fire are honored with this year's Nobel Prize in Physiology or Medicine.

PMID:
17174883
[PubMed - indexed for MEDLINE]
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