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Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy.
Department of Surgery, Division of Endocrine Surgery, University of Michigan, Ann Arbor, Michigan, USA. pbhama@u.washington.edu
BACKGROUND: Desmoid tumors that present as a part of Gardener's syndrome can present very difficult management problems. CASE PRESENTATION: We report a case of intra-abdominal desmoid tumor causing distal small bowel obstruction that complicated the management of a more proximal enterocutaneous fistula from the jejunum. After failure of more conventional management options including imatinib, the patient's disease responded to doxorubicin and ifosfamide. The response resolved the bowel obstruction and allowed small intestinal resection to resolve the enterocutaneous fistula. CONCLUSION: Systemic cytotoxic therapy with doxorubicin and ifosfamide can be useful for patients with complications from intra-abdominal desmoid tumor.
PMID: 17173703 [PubMed]
PMCID: PMC1716167
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Patient Drug Information
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Doxorubicin (Adriamycin PFS® , Adriamycin RDF® , Adriamycin® , ...)
Your doctor has ordered the drug doxorubicin to help treat your illness. The drug is given by injection into a vein.
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Ifosfamide (Ifex® )
Your doctor has ordered the drug ifosfamide to help treat your illness. The drug is given by injection into a vein.
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Imatinib (Gleevec® )
Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers of the blood cells. Imatinib is also used to treat gastrointestinal stromal tumors (GIST; a type of tumo...