Format

Send to:

Choose Destination
See comment in PubMed Commons below
Methods Mol Biol. 2007;361:63-91.

Wnt signaling as a therapeutic target for cancer.

Author information

  • 1Clinical Research Unit for Gastrointestinal Cancers, Department of Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

Abstract

The Wnt/beta-catenin signaling pathway is tightly regulated and has important functions in development, tissue homeostasis, and regeneration. Deregulation of Wnt/beta-catenin signaling is frequently found in various human cancers. Eighty percent of colorectal cancers alone reveal activation of this pathway by either inactivation of the tumor-suppressor gene adenomatous polyposis coli or mutation of the proto-oncogene beta-catenin. Activation of Wnt/beta-catenin signaling has been found to be important for both initiation and progression of cancers of different tissues. Therefore, targeted inhibition of Wnt/beta-catenin signaling is a rational and promising new approach for the therapy of cancers of various origins.

PMID:
17172707
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk