Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Invest Dermatol. 2007 Jan;127(1):8-10.

Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis.

Author information

  • 1Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom. w.h.i.mclean@dundee.ac.uk

Abstract

Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.

Comment on

PMID:
17170718
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk