Fitoterapia. 2007 Feb;78(2):120-4. Epub 2006 Nov 14.

Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour.

Rajkumar R, Kumar EP, Sudha S, Suresh B.

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J.S.S. College of Pharmacy, Ooty, India. rajkumarrna@yahoo.com

Abstract

The Celastrus oil, extracted from seeds of Celastrus paniculatus tested at 2 dose levels (1 and 1.5 g/kg), exhibited significant anxiolytic activity and did not produce tolerance. The non-sedative nature and reversal of buspirone induced behaviour (in open field exploration) point to the serotonergic mechanism underlying the anxiolysis, inspiring further research.

PMID:: 17169502; [PubMed - indexed for MEDLINE]

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