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J Neuroimmunol. 2007 Feb;183(1-2):189-99. Epub 2006 Dec 13.

Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.

Harp C, Lee J, Lambracht-Washington D, Cameron E, Olsen G, Frohman E, Racke M, Monson N.

Source

Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

Previous findings from our laboratory demonstrated that some clonally expanded cerebrospinal fluid (CSF) B cells from MS patients exhibit diminished mutation targeting patterns in comparison to typical B cells selected in the context of germinal centers (GCs). In order to determine whether the overall CSF B cell repertoires adhered to mutation patterns typical of GC-selected B cells, we analyzed the immunoglobulin repertoires from CSF B cells of 8 MS patients for mutation characteristics typical of GC-derived B cells. Mutation targeting was preserved. Thus, clonal expansion of some CSF B cells may occur independently of GC, but the CSF B cell pool is governed by typical GC selection. Interestingly, the heavy chain CDR3's of CSF B cells from MS patients had a net acidic charge, similar to GC-derived B cells, but a tendency towards longer CDR3's, consistent with autoreactive B cells. How these findings may support current hypotheses regarding the origin of CSF B cells is discussed.

PMID:: 17169437; [PubMed - indexed for MEDLINE]
PMCID:: PMC2034205

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Receptors, Antigen, B-Cell

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Multiple Sclerosis - MedlinePlus Health Information

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