Mini Rev Med Chem. 2006 Dec;6(12):1311-20.

Chondroitin sulphate: antioxidant properties and beneficial effects.

Campo GM, Avenoso A, Campo S, Ferlazzo AM, Calatroni A.

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Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, 98125-Messina, Italy. gcampo@unime.it

Abstract

Most biological molecules exhibit more than one function. In particular, many molecules have the ability to directly/indirectly scavenge free radicals and thus act in living organisms as antioxidant. During oxidative stress, the increase of these molecules levels seems to be a biological response that in synergism with the other antioxidant defence systems may protect cells from oxidation. Among these structures, chondroitin sulphate is a biomolecule which has increasingly focused the interest of many research groups due to its antioxidant activity. This review briefly summarises the action of chondroitin sulphate in reducing molecular damage caused by free radicals and associated oxygen reactants.

PMID:: 17168807; [PubMed - indexed for MEDLINE]

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NF-kB and caspases are involved in the hyaluronan and chondroitin-4-sulphate-exerted antioxidant effect in fibroblast cultures exposed to oxidative stress. [J Appl Toxicol. 2008]
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Cited by 1 PubMed Central article

The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation. [Br J Pharmacol. 2008]
The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation.
Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, D'Ascola A, Rugolo CA, Calatroni A. Br J Pharmacol. 2008 Nov; 155(6):945-56. Epub 2008 Aug 25.

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