Rev Med Interne. 2007 Jan;28(1):46-7. Epub 2006 Sep 27.

[Silent thyroiditis in a patient under lithium therapy].

[Article in French]

Garcia C, Mayaudon H, Dupuy O, Le Berre JP, Bordier L, Bauduceau B.

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Service d'endocrinologie, hôpital d'instruction des Armées-Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France.

Abstract

While hypothyroidism secondary to treatments by lithium are well known, cases of hyperthyroidism are less common. A 48 years old patient under lithium carbonate from about 10 years ago presents hyperthyroidism without any auto-immunity biological markers, associated with a very low thyroid tracer uptake on scintigraphy. Treatments by anti thyroid agents will be necessary during months in order to normalize the hormone level, whereas lithium is maintained. Only few tens of cases of hyperthyroidism related to lithium have been reported in the literature. This observation shows the importance of the thyroid hormonal follow up for patients under lithium, in order to treat them before the outbreak of a thyroid dysfunction. The causal toxic mechanism is still unclear, and may be related with a direct damage of lithium to follicular cells.

PMID:: 17166635; [PubMed - indexed for MEDLINE]

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