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Org Lett. 2006 Dec 21;8(26):5943-6.

Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction.

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  • 1Unité de chimie organique et médicinale, Université catholique de Louvain, Place Louis Pasteur, 1, 1348 Louvain-la-Neuve, Belgium.


[Structure: see text] An efficient method for the enantioselective tandem reductive aldol reaction of methyl acrylate with aldehydes is reported. By using a copper(I) precursor and a proper diphosphane ligand, high reactivities can be reached, with TOF up to 40,000 h-1. Taniaphos-based ligands lead to enantioselectivities of up to 97% in the case of the major syn diastereoisomer.

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