Nano Lett. 2006 Dec;6(12):2826-32.

Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation.

Seleverstov O, Zabirnyk O, Zscharnack M, Bulavina L, Nowicki M, Heinrich JM, Yezhelyev M, Emmrich F, O'Regan R, Bader A.

Source

Center for Biotechnology and Biomedicine (BBZ), University of Leipzig, D-04103 Leipzig, Germany. alex_seleverstov@yahoo.de

Abstract

Lately certain cytotoxicity of quantum dots (QDs) and some deleterious effects of labeling procedure on stem cells differentiation abilities were shown. In the present study we compared cytotoxicity and intracellular processing of two different-sized protein-conjugated QDs after labeling of the human mesenchymal stem cells (hMSC). An asymmetrical intracellular uptake of red (605 nm) and green (525 nm) quantum dots was observed. We describe for the first time a size-dependent activation of autophagy, caused by nanoparticles.

PMID:: 17163713; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Labeling of mesenchymal stem cells with bioconjugated quantum dots. [Methods Mol Biol. 2011]
Labeling of mesenchymal stem cells with bioconjugated quantum dots.
Shah BS, Mao JJ. Methods Mol Biol. 2011; 680:61-75.
Labeling and imaging of human mesenchymal stem cells with quantum dot bioconjugates during proliferation and osteogenic differentiation in long term. [Conf Proc IEEE Eng Med Biol So...]
Labeling and imaging of human mesenchymal stem cells with quantum dot bioconjugates during proliferation and osteogenic differentiation in long term.
Shah B, Clark P, Stroscio M, Mao J. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1470-3.
Applications of mesenchymal stem cells labeled with Tat peptide conjugated quantum dots to cell tracking in mouse body. [Bioconjug Chem. 2008]
Applications of mesenchymal stem cells labeled with Tat peptide conjugated quantum dots to cell tracking in mouse body.
Lei Y, Tang H, Yao L, Yu R, Feng M, Zou B. Bioconjug Chem. 2008 Feb; 19(2):421-7. Epub 2007 Dec 15.
Review Fate of micelles and quantum dots in cells. [Eur J Pharm Biopharm. 2007]
Review Fate of micelles and quantum dots in cells.
Maysinger D, Lovrić J, Eisenberg A, Savić R. Eur J Pharm Biopharm. 2007 Mar; 65(3):270-81. Epub 2006 Sep 1.
Review Quantum dots - nano-sized probes for the exploration of cellular and intracellular targeting. [Eur J Pharm Biopharm. 2008]
Review Quantum dots - nano-sized probes for the exploration of cellular and intracellular targeting.
Hild WA, Breunig M, Goepferich A. Eur J Pharm Biopharm. 2008 Feb; 68(2):153-68. Epub 2007 Jun 15.

See reviews... See all...

Cited by 10 PubMed Central articles

Selective targeting of microglia by quantum dots. [J Neuroinflammation. 2012]
Selective targeting of microglia by quantum dots.
Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, et al. J Neuroinflammation. 2012 Jan 24; 9:22. Epub 2012 Jan 24.
EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells. [PLoS One. 2011]
EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells.
Yokoyama T, Tam J, Kuroda S, Scott AW, Aaron J, Larson T, Shanker M, Correa AM, Kondo S, Roth JA, et al. PLoS One. 2011; 6(11):e25507. Epub 2011 Nov 7.
Distinct biological effects of different nanoparticles commonly used in cosmetics and medicine coatings. [Cell Biosci. 2011]
Distinct biological effects of different nanoparticles commonly used in cosmetics and medicine coatings.
Yu JX, Li TH. Cell Biosci. 2011 May 19; 1(1):19. Epub 2011 May 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Quantum dots for human mesenchymal stem cells labeling. A size-dependent autopha...
Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation.
Nano Lett. 2006 Dec ;6(12):2826-32.

PubMed
The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregati...
The peptide Glu-His-Ile-Pro-Ala binds fibrinogen and inhibits platelet aggregation and adhesion to fibrinogen and vitronectin.
Proc Soc Exp Biol Med. 1991 Oct ;198(1):649-55.

PubMed
Fluorogenic label for biomolecular imaging.
Fluorogenic label for biomolecular imaging.
ACS Chem Biol. 2006 May 23 ;1(4):252-60.

PubMed
Sibling cases of Vici syndrome: sleep abnormalities and complications of renal t...
Sibling cases of Vici syndrome: sleep abnormalities and complications of renal tubular acidosis.
Am J Med Genet A. 2007 Jan 15 ;143(2):189-94.

PubMed
Prospective study of vitamins C, E, and A and carotenoids and risk of oral prema...
Prospective study of vitamins C, E, and A and carotenoids and risk of oral premalignant lesions in men.
Int J Cancer. 2007 Mar 1 ;120(5):970-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: