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Semin Immunol. 2007 Apr;19(2):127-35. Epub 2006 Dec 11.

Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.

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  • 1RIKEN Research Center for Allergy and Immunology, Mucosal Immunity Laboratory, Yokohama, Kanagawa 230-0045, Japan.


Our intestine is colonized by an impressive community of bacteria, that has profound effects on the immune functions. The relationship between gut microbiota and the immune system is one of reciprocity: bacteria have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues (GALT) plays a key role in shaping the repertoire of gut microbiota. In this review we discuss new insights into the role of IgA in the maintenance of immune homeostasis and the reciprocal interactions between gut B cells and intestinal bacteria.

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