The purpose of the present cross-sectional study was to identify components of risk variables associated with metabolic syndrome in Asian Indian adolescents. The sample included 400 adolescents (boys = 200; mean age, 15.0 +/- 4.5 years; girls = 200; mean age, 14.4 +/- 3.8 years) from Calcutta, India. The following variables were considered: body mass index, waist circumference, sum of four skinfolds, subscapular/triceps ratio, total cholesterol, triglycerides, blood glucose, and systolic, diastolic, and mean arterial pressure. Principal component factor analysis revealed four uncorrelated factors for adolescent boys that cumulatively explained 76.3% of the observed variance of metabolic syndrome. Four factors with overlap between factors 1 and 2 were observed for adolescent girls that cumulatively explained 74.3% of the total variation of metabolic syndrome. The four factors identified were central body fat distribution (factor 1), centralized subcutaneous fat (factor 2), lipids-blood glucose (factor 3), and blood pressure (factor 4). Furthermore, the first two factors, i.e., central body fat distribution and centralized subcutaneous fat, cumulatively explained more than 46% (46.5% for boys; 46.4% for girls) of the observed variation of metabolic syndrome. Since more than one factor was identified for metabolic syndrome, more than one physiological mechanism could account for the clustering of risk variables of metabolic syndrome in Asian Indian adolescents. Factor analysis of Asian Indian adults also revealed four uncorrelated factors, similar to the present factors, therefore warranting intervention as early as adolescence.