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Neurology. 2006 Dec 12;67(11):2039-41.

Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation.

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  • 1Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave., Suite 106, Madison, WI 53705, USA.


We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs.

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