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Neurology. 2006 Dec 12;67(11):2039-41.

Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation.

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  • 1Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave., Suite 106, Madison, WI 53705, USA. ceg@medicine.wisc.edu

Abstract

We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs.

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