Abstract
Principal rotenoids (deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3-30microM) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti-proliferative activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Differentiation / drug effects*
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Cell Proliferation / drug effects*
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Convolvulaceae / chemistry*
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Enzyme Precursors / metabolism
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Fibrosarcoma / drug therapy*
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Fibrosarcoma / pathology
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Flavonoids / pharmacology*
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Gelatinases / metabolism
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HL-60 Cells / drug effects
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Humans
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Matrix Metalloproteinase 9 / metabolism
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Metalloendopeptidases / metabolism
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Neoplasm Invasiveness / prevention & control*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Rotenone / chemistry
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Rotenone / pharmacology*
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Tumor Cells, Cultured / drug effects
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U937 Cells / drug effects
Substances
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Enzyme Precursors
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Flavonoids
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Plant Extracts
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Rotenone
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Gelatinases
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Metalloendopeptidases
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pro-matrix metalloproteinase 9
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progelatinase
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Matrix Metalloproteinase 9