FEBS Lett. 2006 Dec 22;580(30):6903-8. Epub 2006 Nov 30.

Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4.

Palacios A, Garcia P, Padró D, López-Hernández E, Martín I, Blanco FJ.

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NMR Group, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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FEBS Lett. 2010 Feb 5;584(3):643.

Abstract

Plant homeodomain (PHD) fingers are frequently present in proteins involved in chromatin remodelling, and some of them bind to histones. The family of proteins inhibitors of growth (ING) contains a PHD finger that bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear phosphoinositide receptors. We have determined the structure of ING4 PHD, and characterised its binding to phosphoinositides and histone methylated tails. In contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar affinity to the different methylation states of histone-3 at lysine 4.

PMID:: 17157298; [PubMed - indexed for MEDLINE]

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The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin. [J Mol Biol. 2010]
The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin.
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Cited by 13 PubMed Central articles

Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53. [J Biol Chem. 2011]
Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53.
Guo Q, Fast W. J Biol Chem. 2011 May 13; 286(19):17069-78. Epub 2011 Mar 22.
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. [J Biol Chem. 2011]
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9.
Mansfield RE, Musselman CA, Kwan AH, Oliver SS, Garske AL, Davrazou F, Denu JM, Kutateladze TG, Mackay JP. J Biol Chem. 2011 Apr 1; 286(13):11779-91. Epub 2011 Jan 28.
ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma. [J Oncol. 2011]
ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.
Li X, Kikuchi K, Takano Y. J Oncol. 2011; 2011:963614. Epub 2010 Oct 28.

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Structures reported by this article

Plan Homeodomain Finger Of Tumour Supressor Ing4

PDB: 2K1J

Source: Homo sapiens

Method: Solution Nmr

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