Haplotype probabilities for multiple-strain recombinant inbred lines.

Research Unit Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany.

Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2(n)-way intermated recombinant inbred populations (IRIP).

PMID: 17151250 [PubMed - indexed for MEDLINE]

PMCID: PMC1840090