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Genetics. 2007 Mar;175(3):1533-7. Epub 2006 Dec 6.

Telomere dysfunction drives increased mutation by error-prone polymerases Rev1 and zeta in Saccharomyces cerevisiae.

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  • 1Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010-0269, USA.

Abstract

Using a model system, we have shown that replicative senescence is accompanied by a 16-fold increase in base substitution and frameshift mutations near a chromosome end. The increase was dependent on error-prone polymerases required for the mutagenic response to DNA lesions that block the replication fork.

PMID:
17151233
[PubMed - indexed for MEDLINE]
PMCID:
PMC1840081
Free PMC Article

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