J Virol. 2007 Feb;81(4):2065-8. Epub 2006 Dec 6.

Electron cryotomography reveals the portal in the herpesvirus capsid.

Source

Graduate Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Herpes simplex virus type 1 is a human pathogen responsible for a range of illnesses from cold sores to encephalitis. The icosahedral capsid has a portal at one fivefold vertex which, by analogy to portal-containing phages, is believed to mediate genome entry and exit. We used electron cryotomography to determine the structure of capsids lacking pentons. The portal vertex appears different from pentons, being located partially inside the capsid shell, a position equivalent to that of bacteriophage portals. Such similarity in portal organization supports the idea of the evolutionary relatedness of these viruses.

PMID:: 17151101; [PubMed - indexed for MEDLINE]
PMCID:: PMC1797573

Free PMC Article

Images from this publication.See all images (4) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

UREA - HSDB

Supplemental Content

Save items

Related citations in PubMed

Assembly of the herpes simplex virus capsid: identification of soluble scaffold-portal complexes and their role in formation of portal-containing capsids. [J Virol. 2003]
Assembly of the herpes simplex virus capsid: identification of soluble scaffold-portal complexes and their role in formation of portal-containing capsids.
Newcomb WW, Thomsen DR, Homa FL, Brown JC. J Virol. 2003 Sep; 77(18):9862-71.
Visualization of the herpes simplex virus portal in situ by cryo-electron tomography. [Virology. 2007]
Visualization of the herpes simplex virus portal in situ by cryo-electron tomography.
Cardone G, Winkler DC, Trus BL, Cheng N, Heuser JE, Newcomb WW, Brown JC, Steven AC. Virology. 2007 May 10; 361(2):426-34. Epub 2006 Dec 22.
Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes. [J Mol Biol. 1993]
Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes.
Newcomb WW, Trus BL, Booy FP, Steven AC, Wall JS, Brown JC. J Mol Biol. 1993 Jul 20; 232(2):499-511.
Review The herpes simplex virus type 1 particle: structure and molecular functions. Review article. [APMIS. 1994]
Review The herpes simplex virus type 1 particle: structure and molecular functions. Review article.
Haarr L, Skulstad S. APMIS. 1994 May; 102(5):321-46.
Review Effects of salts on internal DNA pressure and mechanical properties of phage capsids. [J Mol Biol. 2011]
Review Effects of salts on internal DNA pressure and mechanical properties of phage capsids.
Evilevitch A, Roos WH, Ivanovska IL, Jeembaeva M, Jönsson B, Wuite GJ. J Mol Biol. 2011 Jan 7; 405(1):18-23. Epub 2010 Oct 28.

See reviews... See all...

Cited by 19 PubMed Central articles

Cryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons. [PLoS Pathog. 2011]
Cryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons.
Ibiricu I, Huiskonen JT, Döhner K, Bradke F, Sodeik B, Grünewald K. PLoS Pathog. 2011 Dec; 7(12):e1002406. Epub 2011 Dec 15.
The molecular biology of frog virus 3 and other iridoviruses infecting cold-blooded vertebrates. [Viruses. 2011]
The molecular biology of frog virus 3 and other iridoviruses infecting cold-blooded vertebrates.
Chinchar VG, Yu KH, Jancovich JK. Viruses. 2011 Oct; 3(10):1959-85. Epub 2011 Oct 20.
A physical link between the pseudorabies virus capsid and the nuclear egress complex. [J Virol. 2011]
A physical link between the pseudorabies virus capsid and the nuclear egress complex.
Leelawong M, Guo D, Smith GA. J Virol. 2011 Nov; 85(22):11675-84. Epub 2011 Aug 31.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Electron cryotomography reveals the portal in the herpesvirus capsid.
Electron cryotomography reveals the portal in the herpesvirus capsid.
J Virol. 2007 Feb ;81(4):2065-8. Epub 2006 Dec 6 .

PubMed
RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis o...
RecA can stimulate the relaxation activity of topoisomerase I: Molecular basis of topoisomerase-mediated genome-wide transcriptional responses in Escherichia coli.
Nucleic Acids Res. 2007 ;35(1):79-86. Epub 2006 Dec 6 .

PubMed
A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell cult...
A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture.
Mol Cell Proteomics. 2007 Mar ;6(3):394-412. Epub 2006 Dec 6 .

PubMed
Inositol trisphosphate receptor in higher plants: is it real?
Inositol trisphosphate receptor in higher plants: is it real?
J Exp Bot. 2007 ;58(3):361-76. Epub 2006 Dec 5 .

PubMed
Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.
Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.
Science. 1991 Aug 23 ;253(5022):912-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: