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Functional role of the cofactor on activation process of L-histidine dependent ribozyme.

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  • 1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.


The activity of an L-histidine dependent ribozyme was analyzed with many pseudo-cofactors to investigate the activation process of the ribozyme. As a result, only L-histidine was able to induce the ribozyme activity among all chemicals used in this study. On the other hand, many L-histidine analogues inhibited the activation of the ribozyme by L-histidine, indicating the binding site permitted the analogues' access. These results suggest that the ribozyme recognizes L-histidine and express its activity highly specifically via an activation process followed by the histidine binding.

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