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Eur J Med Chem. 2007 Apr;42(4):538-43. Epub 2006 Dec 5.

Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids.

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  • 1Anti-infectives Discovery Group, Discovery Research, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad 500 049, India.


With an intention to synergise the antibacterial activity of chalcones and oxazolidinones, several hybrid compounds possessing both chalcone and oxazolidinone moieties were synthesized and tested for antibacterial activity. The hybrid molecules containing heterocycles instead of aromatic ring were found to be active. A SAR study with various heterocycles resulted in a lead molecule 20, which was converted to one of the potent antibacterial compounds 27.

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