Ergot and its alkaloids. [Am J Pharm Educ. 2006]

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1: Am J Pharm Educ. 2006 Oct 15;70(5):98. Links

Ergot and its alkaloids.

Schiff PL.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. pschiff@pitt.edu

This manuscript reviews the history and pharmacognosy of ergot, and describes the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives. A brief discussion of the hallucinogenic properties of lysergic acid diethylamide is also featured. An abbreviated form of the material found in this paper is presented in a 4-hour didactic format to third-professional year PharmD students as part of their study of vascular migraine headaches, Parkinson's disease, and naturally occurring hallucinogens/hallucinogen derivatives in the modular course offering Neurology/Psychiatry.

PMID: 17149427 [PubMed - indexed for MEDLINE]

PMCID: PMC1637017

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[Pharmacological basis for the therapeutic use of ergot alkaloids] [Presse Med. 1983]
Indolealkylamine and phenalkylamine hallucinogens: a brief overview. [Neurosci Biobehav Rev. 1982]
Effect of a chiral 4-alkyl substituent in hallucinogenic amphetamines. [J Med Chem. 1995]
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Ergot and its alkaloids.

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