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Arch Gen Psychiatry. 2006 Dec;63(12):1386-95.

Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men.

Author information

  • 1McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada.

Abstract

CONTEXT:

In animals, repeated exposure to stimulant drugs leads to an enhanced drug-induced psychomotor response and increased dopamine release. This phenomenon, known as sensitization, may confer vulnerability to drug addiction or drug-induced psychosis in humans. A similar phenomenon, referred to as endogenous sensitization, is also believed to play a role in the emergence of positive symptoms in patients with schizophrenia.

OBJECTIVE:

To determine whether behavioral and neurochemical sensitization occur in healthy individuals after limited exposure to amphetamine in the laboratory.

DESIGN:

Open-label, 1-year follow-up of repeated amphetamine administration in healthy volunteers.

SETTING:

Department of Psychiatry, McGill University, and McConnell Brain Imaging Center, Montreal Neurological Institute.

PARTICIPANTS:

Ten healthy men (mean +/- SD age, 25.8 +/- 1.8 years).

INTERVENTION:

Three single doses of amphetamine (dextroamphetamine sulfate, 0.3 mg/kg by mouth) were administered on days 1, 3, and 5.

MAIN OUTCOME MEASURES:

Using positron emission tomography and [11C]raclopride, we measured dopamine release in response to amphetamine on the first exposure (day 1) and 14 days and 1 year after the third exposure.

RESULTS:

The initial dose of amphetamine caused dopamine release in the ventral striatum (a reduction in [11C]raclopride binding). Consistent with a sensitization-like phenomenon, 14 and 365 days after the third dose of amphetamine there was a greater psychomotor response and increased dopamine release (a greater reduction in [11C]raclopride binding), relative to the initial dose, in the ventral striatum, progressively extending to the dorsal caudate and putamen. A high novelty-seeking personality trait and self-rating assessments indicating impulsivity predicted proneness to sensitization.

CONCLUSIONS:

Sensitization to stimulants can be achieved in healthy men in the laboratory. This phenomenon is associated with increased dopamine release and persists for at least 1 year.

PMID:
17146013
[PubMed - indexed for MEDLINE]
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