Ann N Y Acad Sci. 2006 Oct;1082:52-5.

Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.

Ilves H, Kaspar RL, Wang Q, Seyhan AA, Vlassov AV, Contag CH, Leake D, Johnston BH.

Source

SomaGenics, Inc., Santa Cruz, CA 95060, USA.

Abstract

The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.

PMID:: 17145925; [PubMed - indexed for MEDLINE]

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Hepatitis C - MedlinePlus Health Information

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