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Free Radic Biol Med. 2006 Dec 1;41(11):1621-8. Epub 2006 Sep 16.

Tumor macrophage redox and effector mechanisms associated with hypoxia.

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  • Radiation Biology Branch, National Cancer Institute, NIH, 10/B3-B69, 9000 Rockville Pike, Bethesda, MD 20892, USA. SP@nih.gov


Monocytes are recruited from the circulation into solid tumors where they differentiate into macrophages with unique phenotypes. While macrophages utilize oxygen in a broad range of immune effector functions, the generation of reactive oxygen and nitrogen oxide species is less clear in the setting of hypoxia, which can be a prominent feature of solid tumors. The relationships among innate immunity, redox systems, and the plasticity of phenotypic changes tumor-associated macrophages undergo in conjunction with tumor hypoxia will be examined.

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