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Clin Infect Dis. 2007 Jan 1;44(1):69-73. Epub 2006 Nov 28.

Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis.

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  • 1International Research and Programs Branch, Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. pdewan@cdc.gov

Abstract

The sensitivity of an interferon-gamma assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%-78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.

PMID:
17143818
[PubMed - indexed for MEDLINE]
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