Nat Rev Microbiol. 2007 Jan;5(1):48-56. Epub 2006 Dec 4.

Persister cells, dormancy and infectious disease.

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Antimicrobial Discovery Center, Department of Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA. k.lewis@neu.edu

Abstract

Several well-recognized puzzles in microbiology have remained unsolved for decades. These include latent bacterial infections, unculturable microorganisms, persister cells and biofilm multidrug tolerance. Accumulating evidence suggests that these seemingly disparate phenomena result from the ability of bacteria to enter into a dormant (non-dividing) state. The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review.

PMID:: 17143318; [PubMed - indexed for MEDLINE]

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