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Nucleic Acids Res. 2007 Jan;35(Database issue):D363-6. Epub 2006 Nov 16.

euHCVdb: the European hepatitis C virus database.

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  • 1Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1, IFR 128 BioSciences, Lyon-Gerland, France. c.combet@ibcp.fr

Abstract

The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.

PMID:
17142229
[PubMed - indexed for MEDLINE]
PMCID:
PMC1669729
Free PMC Article
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