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Urology. 2006 Dec;68(6):1280-3. Epub 2006 Dec 4.

Prostate cancer and schizophrenia.

Author information

  • 1Stanley Medical Research Institute and Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20815, USA. torreyf@stanleyresearch.org

Abstract

OBJECTIVES:

To assess the incidence of prostate cancer in individuals with schizophrenia.

METHODS:

A MEDLINE search was performed for all studies of "prostate cancer" or "cancer" and "schizophrenia."

RESULTS:

Five studies had age-standardized, site-specific cancer data. All five had a lower standardized incidence ratio for prostate cancer, ranging from 0.49 to 0.76. The incidence of cancer at other sites varied among the studies. Possible explanations included ascertainment bias; genetic factors; antipsychotic drug effects, either by being cancer protective or decreasing testosterone, or both; and lifestyle differences, such as prolonged hospitalization resulting in a decreased opportunity for heterosexual intercourse.

CONCLUSIONS:

The results of this study have revealed that the incidence of prostate cancer in individuals with schizophrenia is significantly lower than expected.

PMID:
17141844
[PubMed - indexed for MEDLINE]
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