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    Biol Psychiatry. 2007 Aug 15;62(4):355-8. Epub 2006 Dec 4.

    Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects.

    Fowler JS, Alia-Klein N, Kriplani A, Logan J, Williams B, Zhu W, Craig IW, Telang F, Goldstein R, Volkow ND, Vaska P, Wang GJ.

    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov

    BACKGROUND: A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects. METHODS: Brain MAO A activity was measured with positron emission tomography and [(11)C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism. RESULTS: There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes. CONCLUSIONS: The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.

    PMID: 17141746 [PubMed - indexed for MEDLINE]

    PMCID: 2712611

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