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Eur J Cancer. 2007 Jan;43(2):351-62. Epub 2006 Dec 1.

Risk of second malignancies in long-term survivors of childhood cancer.

Author information

  • 1Long-term follow-up clinic, Department of Paediatric Oncology, Emma Kinderziekenhuis AMC, Academic Medical Center, Post Box 22660, 1100 DD Amsterdam, The Netherlands.

Abstract

INTRODUCTION:

Childhood cancer survivors are known to be at increased risk for second malignancies.

PATIENTS AND METHODS:

The risk of second malignancies was assessed in 1368 5-year survivors of childhood cancer treated in the Emma Children's Hospital AMC in Amsterdam. The median follow-up time was 16.8 years.

RESULTS:

Sixty two malignancies were observed against 5.4 expected, yielding a standardised incidence ratio (SIR) of 11.2 (95% confidence interval: 8.53-14.4; absolute excess risk: 3.2 per 1000 person-years). New observations were the strongly increased risks of meningiomas (SIR=40) and basal cell carcinomas (SIR=9). Patients whose treatment involved radiotherapy had a 2-fold increased second cancer risk compared to patients with chemotherapy alone.

DISCUSSION:

The relative risk of second malignancies does not decrease till at least 30 years of follow-up. With aging of the survivor cohort this results in a strong increase of the AER, due to the rising background risk of cancer with age.

PMID:
17141498
[PubMed - indexed for MEDLINE]
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