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Nat Rev Mol Cell Biol. 2006 Dec;7(12):932-43. Epub 2006 Nov 8.

Replisome assembly and the direct restart of stalled replication forks.

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  • 1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.


Failure to reactivate either stalled or collapsed replication forks is a source of genomic instability in both prokaryotes and eukaryotes. In prokaryotes, dedicated fork repair systems that involve both recombination and replication proteins have been identified genetically and characterized biochemically. Replication conflicts are solved through several pathways, some of which require recombination and some of which operate directly at the stalled fork. Some recent biochemical observations support models of direct fork repair in which the removal of the blocking template lesion is not always required for replication restart.

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